Human, Rat, Mouse IL23A Rabbit Polyclonal Antibody

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    Terms and Conditions
    Garanzia di rimborso di 30 giorni
    Spedizione: 2-3 giorni lavorativi

    Host: Rabbit

    Isotype: IgG

    Clonality: Polyclonal

    Immunogen: Synthesized peptide derived from human IL23A

    Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

    Concentration: ~1 mg/ml

    Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

    Storage: -20°C for 1 year

    Background:

    Developmental stage:Expressed by newborns dendritic cells.|Associates with IL12B to form the IL-23 interleukin| an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R| activates the Jak-Stat signaling cascade| stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.|induction:Up-regulated by a wide array of pathogens and pathogen-products together with self-signals for danger or injury. Up-regulated in psoriatic dermal tissues| in dendritic cells of multiple sclerosis patients and in tumors.|Belongs to the IL-6 superfamily.|subcellular location:Secreted upon association with IL12B.|subunit:Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23.|tissue specificity:Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).|

    Uniprot accession: Human: Q9NPF7;

    Molecular weight: 20790

    Synonyms: IL23A; Interleukin-23 subunit alpha; IL-23 subunit alpha; IL-23-A; Interleukin-23 subunit p19; IL-23p19

    Reasearch area: Cancer; Immunology; Microbiology

    Target protein: IL23A